The LASAR wasn't a very good example. It worked, but not very well.
The newer setups that are now certified I'm much more interested in. On my list the funds come in.
Angle valve or parallel valve?
That is high compression. And on 100LL when operated normally, I'd expect it to be ok. Plus I recall you saying you flew your Midget Mustang highish altitude and longish trips, which will also lessen the burden on the crank.
12.5:1, egh... I wouldn't do it. But 10:1 would be my normal limit.
Angle valve IO-360 out of an Arrow, I took it as payment in a trade deal with an insurance company for hauling off three planes that got totaled on a ramp by storm damage. I never really intended to put it in anything at the time, did it more as an experiment in what I could make a 360 do, and when I went to store it in a guy's hangar I came across the partially completed airframe and told the guy if he ever finished it, hang that engine on and I'd buy it off him.
12.5:1 with a SB Chevy was common, I don't know many people racing them back then with less unless they had a blower.