This isn't true for the big bore TCM IO520/550 engines with the induction manifold with the short runners that connect upward to the intake ports on the cylinders. The airflow is well balanced as evidenced by the smooth running of these engines when ROP.
On these engines the Gamijectors balance the fuel flow to the cylinders. If the injectors are all of the same size, the rear cylinders will run leanest, followed by the middle cylinders being richer, and the front cylinders being much richer. The reason for this is two fold. First the injectors are continuously injecting fuel into the intake chamber above the intake valve, but the intake valve is only open during a portion of the cycle. When the valve is closed, the fuel is drawn by gravity and the low pressure of the intake manifold down into the manifold. The fuel from the rear cylinder is transported forward into the front two cylinders, enrichening the mixture in both of them. In the same way, the middle cylinder's fuel is transported to the front cylinder, enrichening it even further. The Gamijectors compensate for this by having a larger opening in the rear cylinder (papa bear), a smaller opening for the middle cylinder (mama bear), and the leanest opening for the front cylinders (baby bear).
Engines that have overhead induction systems tend to run smoother and need less correction.
When running ROP, air flow controls power as fuel is in abundance (more than needed for combustion). Running LOP, fuel flow controls power as air is in abundance. If we had an air flow meter in our airplane we could use it to measure power when ROP, but alas we don't, so we look up the power settings in tables that have all the factors that contribute to the amount of air flow is being provided to the engine (manifold pressure, temperature, altitude, RPM). On the lean side, if you have a digital fuel flow indicator, you have all the information you need to establish the power setting.