Ditto the above posts, IFR or VFR doesn't really make any difference. Winds permitting, they will try to land you on 35L/17R right next to Signature.
A few tips for DEN:
You might want to check with Signature as to fees and minimum fuel purchase, etc., it can be a bit pricey (I actually don't know how it would work if you just do a full stop and taxi back for departure.)
Be prepared to "keep your speed up" on final, this may mean not extending gear and flaps, or whatever, until very short final. Though, traffic may be so light it won't matter.
If you do have to taxi from the east side to west, or vice-versa, through the terminal area, say from GA parking by 35L to 34L, they'll probably have you traverse the ramp area on taxiway AA. Be prepared for ground frequency changes, there's one for east side, one for ramp/gate area, and one for west.
On departure, the routine is, as it is at many busy airfields, somewhere during your taxi as you near your assigned runway, ground control will tell you to "monitor tower." After switching frequency, no check-in is required or wanted, the next thing you'll hear is from tower with takeoff clearance, or line up and wait, or hold short, etc. They ex[ect you to be ready to go. There is really no time or place to do a run-up, so either do that while taxiing, or have everything checked before even calling ground for taxi.
Of course, it might be so quiet there now, that all this will be moot. At any rate, have fun!