I was a die-hard Safari user for a long time - Certain things I just got used to, especially the most-visited sites thing when opening a new window or tab, and a generally polished look and feel.
I did keep FireFox for the extremely rare occasions when I'd come across a site that didn't play nice with Safari. I think there were two. However, FireFox was just annoying to me - It technically worked, but it felt klunky and I just didn't get along with it too well, so it stayed as the "backup" browser.
Two months ago, for some reason I decided to give Chrome a try. I posted a thread about it a while ago, and since then it has become my 100% browser. It's CRAZY fast, I haven't yet come across a site that doesn't support it, and did I mention it's FAST? That makes all the difference in the world. In fact, I think everything else on my machine might be faster now since there's still resources to allocate to things besides Safari.
So, I must recommend Chrome... Give it a try, and I think you'll quickly agree.
That said, there are still some things Safari did that I still miss and I'd really like to see Chrome do. I really miss having the blue star showing that a site in my most-visited sites has been updated since I visited it. I miss the ability to quit the browser and come back to right where I was (Safari has a "Reopen all windows from last session" command). I don't like Chrome's display of tabs (you can't see the full title of the pages anywhere), and there's a couple other minor things that I can't think of right now. But in the end, Chrome won me over and I'll keep using it and hoping that they add my "missing" features in someday.