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Domenick
I would not take my medical advice from the NY Times."You shouldn’t try to stave off discomfort by taking a pain reliever before getting the shot. The concern is that premedicating with a pain reliever like acetaminophen (Tylenol) or ibuprofen (Advil, Motrin), which can prevent side effects like arm soreness as well as fever or headache, might also blunt your body’s immune response."
https://www.nytimes.com/2021/04/02/...effects-faq.html?referringSource=articleShare
My lawyer also suggests you not take it from me
Acetaminophen and ibuprofen have somewhat different modes of action though both are COX (1 and 2) inhibitors. In typical small doses, both are weak anti-inflammatories. Basically, they are for pain relief. Vitamin-I will inhibit aspirin's anti-platelet coagulation effects, so if you take prophylactic aspirin, wait an hour or so after taking the aspirin to take the ibuprofen.
I wouldn't worry a whit about taking a low-dose of ibuprofen before the shot for arm pain mediation. It takes 60-90 minutes for generic ibuprofen to take effect.(BTW--I choose ibuprofen over acetaminophen because it works better with my specific biochemistry).
That said, I am conservative in my drug use, so my plan is to wait for side effects to manifest before drugging up.