1. If you're somewhat familiar with talking with approach around the MSP area whether on FF or something similar, then getting a clearance to enter the B by telling them what you want to do isn't that big a deal. It only is a big deal the first time or two until you get comfortable with the procedures and sequences.
2. Probably only 1 or maybe 2 approach freqs at most, then tower, then ground for a full stop. They will tell you what altitudes and headings to fly until cleared for a visual approach, have the ILS programed in so you can follow it down to the correct runway. Prep ahead of time is the key, be familiar with freqs, ILS freqs, runway numbers and taxiway markings and designations beforehand. Have a good airport diagram studied and accessible right in front of you.
3. Not that hard to figure out which runway is which with the ILS, and approach lights in view and a few landmarks beforehand.
4. That's where studying the airport chart beforehand is critical, and having it out in front of you while taxing, and someone familiar is most important. Your only going to taxi back from part way down the runway, not all the way from the far end. If you land on one runway and TO from another, there may be another ground and tower freq to deal with. If it's late at night and you talk to them beforehand with what you want to do they'll help hold your hand. Chances are that you'll be on 12R/30L near Signature, 4/22 is not used very often, so you can forget about that one.
It's like anything else, it's a big deal at first, then it becomes old hat after a while.