I've generally resisted the idea of retrofit big Navigator screens in little airplanes from a money perspective... and possibly UI perspective. I have had trouble justifying the cost of a 750 in lieu of a 650, considering a "linked" iPad provides a bigger and better moving map display without sacrificing any screen real estate. If you're using an iPad linked to your Navigator, as many of us do these days, you're already using the iPad for re-routes and other edits to your flight plan and pushing them to the panel, so why not keep your moving map display there? I fly behind the 750 regularly and love the big display, however the size is such that it's "nice" but not a game changer. It's not big enough to reasonably accommodate chart views, and it's bigger than you really need for everything other than a pretty good size moving map display. I view it as a more comfortable sectional sofa with recliner seats vs. a single love seat (650).
However, one configuration which could really make sense, at least from the small airplane/cramped panel perspective, would be a full "remote" install with audio panel and transponder remoted onto the 750. At that point you're looking at no increase in overall center stack panel space taken, more or less, and the user can choose what he or she wants to use the screen real estate for at a given time... i.e. audio panel, transponder, etc. That is a pretty sleek way to go, although not particularly inexpensive.
The other downside, of course, is you're hoping that single "big screen" or some other single point of failure (power, etc.) within the GTN 750 doesn't fail and and take out some or all of this functionality. I'd sure hate to lose audio panel, GPS, a nav radio, com radio, and my transponder all in one fell swoop.
I wouldn't rule out a 750 at some point in the future for my little TwinCo, but it's a marginal improvement over the 650 for a pretty big panel investment outlay.