It's a bit of a blanket statement. Indeed ISS is not in an optimal orbit for beyond-LEO staging. Both altitude and inclination are somewhat disadvantageous. The optimal orbit would be an equatorial orbit, which guarantees you a window for launch in Ecliptic plane every hour, from where you change the targeting with bit of planning of burn timing and duration. Altitude is a bit of a problem because the residual atmosphere exerts drag.
The orbit was selected to accommodate both Shuttle and Russians. For Soyuz (with crew) and Proton (with larger components) to reach the station, it has to be in the 51.6 deg orbit or higher (at a greater inclination). But Shuttle can only fly to a limited altitude, especially when loaded with heavy station pieces.
Note that limiting the altitude so the station orbits under Van Allen belts simplifies the radiation protection enormously, so it would make sense even if Shuttle were better suitable for delivery to higher orbits.
With all that said, the ISS orbit is not a total loss for staging. Russians fly probes to the Moon from a 51.6 parking orbit. It only necessitates additional maneuvering, such as waiting a couple of days for suitable phasing after undocking from ISS. Not a big penalty for a trip that takes months, IMHO.
Going further, I am a bit believer in co-orbiting in the same plane with ISS. Russians have demonstrated its utility by undocking a Soyuz from Salyut-6 and docking it to Mir. Look at it this way: what if a lifeboat design on Titanic was specified not to keep passengers alive for a day or two, but take them all the way back to Sothhampton? But this is what the current lifeboat situation is on the ISS: the lifeboat has to be a full-blown spaceship that can descend through the atmosphere and land on Earth. Aside from safety, other advantages of co-orbiting are having free-fliers for scientific experiments that are impossible at ISS, because they require a better microgravity, or ability to share communications and other resources (e.g. no need for expensive Luch and TDRS satellites), split administrative control, and so on.
Because of these advantages, I am pretty sure that we're stuck with the 51.6 orbit for many years, and we'll need to learn to use it for expedition staging.