Flying or driving?
If flying, it can be done in a single day as noted above. I assume flying due to the desire to be near airports.
If driving, how long are you willing to drive in a day? I've driven from Bridgewater, NJ to Gary, IN in a day. If I were making that drive between 39N and KSPI, I'd stop at Indianapolis. I've stayed at the Hampton Inn near Lilly several times; nothing special but nothing bad either.
I second the detour to the USAF museum if possible. Leave a couple of days for that visit too.