I watched the MacBook announcement, and stay current with some tech shows, so I'm aware of the single port.
With my purchase, I will have to get a dongle.
http://store.apple.com/us/product/MJ1K2AM/A/usb-c-digital-av-multiport-adapter?fnode=51
At my desk now, my MacBook Pro plugs in with multiple cables: power, 2 USB (one to a hub), video out for my monitor and 1/8" plug for my external speakers.
With the adapter, the charger will plug into the dongle, USB hub for my USB accessories and drives and HDMI for my soon-to-be-purchased new monitor.
Will need to travel with the adapter as well, to have access to GoPro videos on microSD cards via an adapter, and anything else USB that comes along.
But I suppose I'll get used to it quickly. My MacBook Pro spends 95%+ of the time docked anyway, only going mobile for trips.
Like when Apple phased out floppy drives and, later, optical drives, I suspect after an initial awkward period and lots of protest we'll all adapt pretty quickly. Certainly easier to plug in one cable at my desk rather than 5 (assuming I use the monitor's speakers) - 2 if I keep my external speakers.
Oh, and spacing on the keyboard felt natural. Less travel on the keys feels a bit weird, but I'm typing this on an iPad Mini with no travel at all and it feels fine, so I suspect I'll adapt. And I still plan to use my Apple keyboard while at my desk, so again not a huge issue.