I had the electric trim in a 182T wind the trim all the way nose down while at the hold short line for a long takeoff delay. I attempted a takeoff, and it felt ridiculously wrong at rotation, so I aborted the takeoff, pulled off the runway, and then noticed where the trim was.
I might have been able to struggle with the airplane airborne, but it would have taken a whole hell of a lot of effort, and I wasn't exactly in the mood to test that (and on a 7000 foot runway, it would have been utterly unnecessary).
I also had a different 182T autopilot glitch while airborne, where engaging it in pitch mode resulted in runaway nose down trim. It didn't make it all the way to the stop (but it got further than one might expect, because the AP button didn't turn it off), but it took a stupid amount of effort to fight the trim while I wound it back off.