This is a rather hard analysis, as there's nothing in the FAA to indicate whether the plane is still flown by the original builder, and the NTSB doesn't always indicate whether the accident pilot is the original owner.
Still, I made a cut at the issue about seven years ago for a magazine article. Would flag an accident as being flown by a purchaser if 1) The NTSB report said so, or 2) The "manufacturer name" in the FAA registry was different from the current owner's name (manual process, mostly, to catch variations), or 3) The pilot had less time-in-type than the aircraft total time (with a ~2 hour buffer to account for ground test time).
Roughly half the accidents in my EAB database met these criteria. Accidents due to mechanical failures were down, relative to the builder-flown cases. This was expected, as many of the "teething problems" of new homebuilts are taken care of by the time the airplane is sold.
However, pilot error was, in fact, higher for the purchased airplanes...both the "Pilot Miscontrol" (stick-and-rudder errors) and "Pilot Judgement" (VFR into IFR, Fuel Exhaustion) categories.
What was even more interesting was the pilot's time in type at the time of the accident. Purchasers of homebuilts have a higher rate of accidents during the transition period.
The builders of homebuilt aircraft are apparently more dedicated to transition training than purchasers. Part of this higher rate is due to more Fuel Exhaustion and Maneuvering at Low Altitude accidents.
Ron Wanttaja