I'm having the same issue. If I search for plates for KFTW, then click the link for the GPS Rwy 34 approach (
http://poa.areeda.com/dttp/index.php?act=viewDoc&docn=29023), I get IE's standard "Do you want to open or save this file?" (it shows the file name as dttp.pdf, file size 199kb from poa.areeda.com). I click "Open", the progress bar acts like it's downloading the file, then Adobe opens and complains that "There was an error opening this document. The file cannot be found."
If I save the file (instead of picking "open"), the saved file opens up just fine. I cleared my cache and temporary files, same thing.
Test with Firefox 2.0.0.1 works just fine.
Are you setting the MIME response type to "application/pdf" for streaming the file directly back to the user?