I'm sure he was a great guy. The fact that he was doing a charitable flight to help an animal tells me what I need to know about his character.
That said, it made the decision to go to the flight levels for what was a fairly short flight in a non-pressurized aircraft. While this is legal, it's not a good idea. And yes, I've done it before, and don't plan on doing it again, especially single pilot. In a pressurized aircraft, if the pressurization system fails you have a certain amount of time to put on O2 and get down to a better altitude. Pressurized aircraft also give you a big warning when you get above a particular cabin altitude (in the 414 it's 10k feet, usually 10-12k is the number). So your time of useful consciousness starts ticking then. In a non-pressurized aircraft, you're on O2 and if that fails (either by running out, running low to where your flow goes down, line gets kinked, etc.) you start running into your time of useful consciousness, and unless you're actually checking your pulse-ox as regularly as you should be (which most people don't in my experience), you probably will start feeling good, completely forget about the pulse-ox, and then fall asleep.
Pressurization isn't fool-proof, of course (look at that TBM a few years ago), but it gives you another layer of protection when operating in an inherently hostile environment for our bodies.
We should all be cautious about flight in altitudes where our bodies won't inherently stay awake. This happened to another Cirrus pilot at 15k feet a few years ago as I recall. Unfortunately, it will continue to happen.
RIP, and condolences to the friends and family of someone who seems to have been a great guy.