As others have said, you need to know the limitations of your autopilot installation. It will have minimum engagement and disengagement altitudes. It will also have a pre-flight test procedure and non-normal procedures. Many GA pilots ignore these but, especially if you're using the A/P in IMC, you really should do and know them.
When flying IMC with an autopilot, you must maintain proficiency both with, and without, the autopilot. Trying to use an unfamiliar autopilot in a busy IMC situation can, and has, caused violations and accidents. If you are proficient with your autopilot it can be a great workload reducing tool.
Use the autopilot as a tool to manage your workload. Assuming you are already proficient, hand fly more when the weather is good and ATC workload is low. As the weather deteriorates and/or ATC workload increases, use the autopilot more to manage the workload and maintain situational awareness.
Practice de-automation strategies for situations where you need the airplane to respond quicker than you can program the automation or when there is confusion about what the autopilot is doing. i.e. drop from NAV to HDG while reprogramming a new clearance so that your turn on-course isn't delayed. Drop to HDG and V/S when the autopilot isn't doing what you expect so that you still have some help from the autopilot while you figure out what is wrong with the programing for the more advanced features. If everything is going wrong, click it all off and go back to hand flying to ensure that the aircraft is doing what you intend. etc.
1. Know the published limitations of your A/P
2. Perform the applicable pre-flight tests on your A/P
3. Know and practice the applicable non-normal procedures of your A/P
4. Include practice in flying procedures both with, and without, the A/P so that you're proficient using either method.
5. De-automate in stages, as needed, to ensure that aircraft control and adherence to ATC clearances in navigation and altitude are maintained.