It doesn't matter at all unless you lose comm. In any other case, you'll always end up flying a route you can fly, getting either a clearance via a route you can navigate yourself to an IAF, vectors to final, or a navigable routing or vectors to a position from which you can see the airport and fly a visual approach. So, what happens if you lose comm?
Assuming you're not in VMC (in which case you remain in VMC and fly under VFR to the nearest practicable airport, land, and call ATC on the phone), the 91.185(c) tells you to fly the route you were cleared/expected/filed. If that route is one you can fly with your own onboard equipment, and leads to/through an IAF for an approach you can fly, it's easy -- you fly that route to that IAF, hold there until your ETE runs out, descend to the IAF altitude, shoot the approach, and land. If your route does not take you to/through an IAF, but does take you through a transition/feeder fix, you go to that fix and straight on to the IAF from which the approach commences, hold there until your ETE runs out, descend to the IAF altitude, shoot the approach, and land. See 91.185(c)(3) for details.
But what if your route does not take you to an IAF or transition/feeder fix that leads to an IAF? Or your route goes direct to an airport with no navaid (and you don't a nav system that allows navigating directly to that airport from your last fix before the airport)? Now where do you go if you lose comm? Obviously you'll do whatever you have to do to get on the ground safely (with 91.3(b) to back you up if you're questioned on any deviation from 91.185), but ATC has a problem, too, trying to guess where you'll go (so they can get other aircraft out of your way), since it's hard to predict what you'll do since the regulatory procedure doesn't cover that part -- you don't have a means to go to the clearance limit and then to an IAF without first going somewhere else (which you will choose in the cockpit but be unable to tell ATC).
For those reasons, particularly if you don't have a point-to-point nav system like an IFR GPS aboard, ATC has the best idea of what to expect from you in event of lost comm if you file to your destination through an IAF to which you can navigate with only your onboard equipment. However, other than in a lost comm situation (and how often does it happen that some loses all communication with the ground including cell phone/handheld but still has navigational capability?), it doesn't really matter.