Cylinder deactivation by itself isn't too bad these days, it does depend on the implementation. I'm not familiar with the Ford implementation on the 5.0. On the Hemis, they use different lifters (they call it their "MDS" system) which shuts off 4 cylinders. That seems to work quite well so long as you change the oil, the issues seem to be with the lifters having issues when you get dirty oil. I wouldn't be too worried about that. The big thing I don't like about that setup is that it makes for a heavier valvetrain.
Auto start-stop is a feature that I do not like, especially on turbocharged engines. We turn it off on my wife's Alfa. On my friend's Mini, it caused/contributed to the timing cover to start leaking.
I looked a bit more into the Coyote 5.0 setup for oil pump and camshaft drive. It reminded me a good bit of the 4.4L V8 in the BMW 740iL we used to have (pre-VANOS). Similar architecture in general being a DOHC 32-valve V8. The oil pump on that was driven by a small chain. Sometimes people replaced it when they did the timing chains (which was a thing on those engines, mainly due to the tensioners but mine had shown stretch after something like 160k miles), but most people didn't and it usually wasn't an issue. Timing/cogged belt technology has come a long way from the 1980s when we first started to see them with generally 60k mile intervals. I used to not like timing belts because of that replacement interval, but I suppose it doesn't bother me as much these days.
For your standard distributor type engine of course you've got an oil pump shaft that goes from the distributor down to the oil pump, which works but those shafts can break (especially if you put in a high volume/high pressure pump) and the risk is that it comes loose/out when you pull the distributor. On my Cobra (351W) even though I'm not running a distributor, I had to put something in there to drive the oil pump, and when with an ARP oil pump shaft. All designs have their pros and cons.
Which reminds me, I need to work on that