Sure.
You know how I'm always ranting about how I always go? That has screwed up some things.
1) With freezing rain forecast over Chicago I once had to land in Indiana, rent a car, and drive the rest of the way to my appointment. I made it on time, but boy did it suck driving back to Indiana to pick up the airplane.
2) Due to the same weather system, I had to cancel a meeting in Texas the next day.
3) On a trip to St. Louis, a weather system over that entire area forced me to fly a Cirrus at 4,000 (the MEA) with a 6,000 foot freezing level due West to Mississippi and then a cut north to St. Louis. The trip took much longer...but we made it.
4) On a trip from NC back to GA one morning, the combination of the new-to-me 310, my not having been to SimCom yet, a low ceiling, cold temps, and recent maintenance forced me to sit on the ground for six hours waiting for weather to clear. I know I could have just blasted off and found a layer, but I wasn't comfortable.
5) All the times I've gotten oil on my business shirt
6) I once ripped a $90 pair of pants in a C172.
I could go on and on, but NONE of the above is as bad to me as the guy coughing in my face as I was sitting cramped for 4 hours, watching 'flight attendants' eat a hot meal ONE hour into the flight, and having to buy a cold, stale sandwitch, starving, THREE hours into the flight, having bought and paid for a first class ticket, and riding in coach, because I got to the ticket counter 1 minute too late. ;-)