This is why government intervention in the market is necessary and why Pharma is so desperately working to keep that from happening. And, unfortunately, succeeding.
Airedale, (and to a lesser extent, Chip) your nice sounding polemic is confounded, unfortunately by fact. I don't like defending pharma but you display a very very limited understanding. It goes thus:
A drug Co. wants to develop a new drug.
If identifies 20 compounds, related to each other that might have the required effects.
The do animal testing mostly for toxicity. If some/any pass, then the promising ones are slated for human testing....majority of the time outside the CONUS. There are then phase 1 human toxicity trials. and they cost huge bucks. If one of the makes it (livers don't rot, people don't go blind, etc) then they start worrying about efficacy. You don't worry about efficacy if the drug is going to kill. The efficacy trials are done in the US and abroad and require institutional review board approvals.
Now remember, we are developing a handful of compounds. and many will still flunk human toxcitiy observations. Femember, the rats dont' tell the whole story.
Let's say the company lucks out and the data are good. Then it's to the FAA review process, which is at least 30 months.
So now it has been 11-13 years since the patents were taken out, and the patent runs out at year 18.
The company has to recover all the costs for all 20 drugs' devleopment and recover them from the one that is successful, all the costs of the other 19, over 13 years it has taken (average) and do so in just five years. So the new mega drug costs Mega.
Now, say you're Canada. The assembly has legislated the price of losartan (which recently went generic). Canada orders 10 million pills and offers 50 cents per pill. To the drug maker this is just extra money so they ship 10 million pills and collect 5 mil. That pill used to cost $4.00 until it went generic. But the costs had already been incurred, and the 5 Mil to physically make the pills probably incrementally cost about 1 cent a tab to manufacture and ship (all the machinery is there already). Easy money.
What Canada has done, is to Medicare cost shift on the US manufacturers. If we do the same thing here at home, there will be no way to recover the costs of the 19 failed drug development trials. Innovation stops. Recent innovations are the Hep C curative drugs, control of HIV to normal life expectancy, and I sure hope a new drug for TB.
Why do we have drug resistant TB? Because other countries get ethambutol and isoniazid for 0.1 cents per pill....it's so cheap you buy them without Rx, on the pharmacy streets in Asia and Latin America. But if we don't send them the pills, the hue and cry! Genocide!
*****
So we permit the rest of the world to medicare us; we pay retail they do not (just as those not on medicare subsidize the medicare population), because if we do not do so, innovation will certainly cease. The riskier the proposition, the more potential profit has to be there to support the gamble. How much wall street money do they think they will attract if the pill will sell for 1 cent per pill?
Do you really want us to taxpayer fund drug research directly, oh I just love that! It would be like Air Force procurement. [/sarcasm off]. The government can make it worse. They're here to help.