My ex lost a relative. Guy was 40, extremely fit, never smoked or drank, dropped dead on the handball court. They did an autopsy, found his arteries clogged, slapped his 18-year-old son in the hospital for tests. Kid was on cholesterol-lowering drugs from then on. High cholesterol can be a genetic condition (actually it may always have more to do with genetics than diet). A friend of mine died of cirrhosis of the liver and was a very, very light drinker (half a glass of wine once in awhile). He managed to live into his 80s, but his quality of life was pretty bad the last few years. It was the same deal: bad genes. You just never know.