I'm not ever going to argue that a twin is "safer" or "less safe" than a single engine airplane.
What I will argue is NO airplane is "safe" in the hands of a pilot that tries to fly it outside it's known flight envelope. Even a Cessna 150 will try to kill you if you disrespect this fact - but the faster, higher performance airplanes generally try to kill you faster. There's just no substitute for pilot proficiency.
Every airplane has multiple failure modes. No argument with your basic premise "
Twins require more knowledge than singles..." The more complex the airplane the more the number of potential failure modes, and that certainly applies when comparing a twin to a single. It also applies when comparing a simple, slow speed, low horsepower single engine airplane to a more complex single engine. It wasn't the Cessna 150 or 172 that earned the moniker "Doctor Killer".
Even that airplane with the parachute (I have become a fan of the Cirrus CAPS system, even though I don't own one) can bite quickly, and even lethally, if one tries to fly it outside the envelope, as this terrible 2016 SR20 accident at Houston Hobby amply demonstrated:
http://www.kathrynsreport.com/2016/06/cirrus-sr20-n4252g-safe-aviation-llc.html
"...Data retrieved from the airplane revealed that, during the go-around, the pilot did not follow the recommended go-around procedure; specifically, the pilot did not attain a speed between 81 to 83 knots indicated airspeed (KIAS) before raising the flaps. Rather, the airplane's airspeed was 58 KIAS when the pilot raised the airplane's flaps while in a left turn, which resulted in exceedance of the critical angle of attack and a subsequent aerodynamic stall and spin into terrain..."
There's just no substitute for pilot proficiency, no matter what type of airplane one is discussing.