"Unsafe"? Oh, I don't know if it's unsafe. I do know that it's less so -- that safety margins and options are reduced.
Look, just for example, at the POH performance predictions for a C-172. They suggest that a 10% reduction in power at SL will reduce takeoff distances by about 9%, and rate-of-climb by about 7%. If anything necessitates a takeoff abort, then that reduced-power pilot will have less room (and less time) in which to put the plane back on the runway or its overrun, before instead having to "put it into the trees" or "land it downtown".
Is it "unsafe" to perform an intersection takeoff in that same C-172 from a mid-field intersection on a 4000' runway? No! The remaining 2000' of runway still provides the proposed "200%+ of runway required". Until ... something goes wrong, and he needs that runway behind him (or, needs that runway that would have been remaining, had he instead performed his takeoff at full power).
Engine roughness or catastrophic failure, an abnormal engine parameter (lost oil pressure, CHT runaway, low manifold pressure, prop overspeed), an improperly-secured engine cowl pops open, smoke in the cockpit or oil spray on the windshield, a controllability problem (aft CG, or mechanical failure of a control linkage), airspeed indication failure, attitude indication failure on an instrument departure. Probably others.