Ok, mostly good points. I should say, it would be a wash for the vast majority of taxpayers. It would be a wash for OP who states his income is $75K (no phase-out at his income level, etc.). Charitable contributions may be deducted so long as they constitute less than 30%-50% of AGI (depending on type of organization). This would be true for OP even at the lower limit. Even if he couldn't deduct the entire amount, he would still probably be able to carry forward for the next 5 years, but I doubt he wouldn't be able to deduct in the first place.
The standard deduction for single is only $6,200 and $12,400 for married, so if you're single there's no reason you wouldn't itemize and if you're married it's hard to believe you couldn't come up with an additional $2,400 of deductions, especially if you have the money available to be making $10K donations -- your state taxes alone would probably be well over $2,400, let alone mortgage interest, etc.
Here:
http://www.irs.gov/uac/Can-I-Deduct-My-Charitable-Contributions?
Also, if you are legally separated you are considered single, even if not divorced. What would be the circumstances in which you wouldn't be able to claim the charitable deduction if married filing separately (assuming within the AGI limits, etc.)?