Well you can always minimize time spent out of glide distance to an airport, to the extent possible, but in many parts of the country it isn't possible in a NA piston single to go very far and remain always within glide distance because airports are too few and far between. That's pretty much the case here in VT - in my Cardinal, I couldn't get high enough to always be within glide distance of an airport, and even if you could eventually get high enough, in the meantime you'd be out of glide distance during the climb. With a turbo, it is perhaps different, if your climb performance is good enough, and if you're willing to always fly high. But with most piston singles you'd be limited to pattern work or at best a few select routes to a few select destinations, so you can reduce your exposure to some extent but never completely eliminate it if you want to use your plane for transportation.