In my new-hire class, about 1/3 came from aviation universities, including my roommate (yes, they paired us up in housing unless we wanted to pay to get a room to ourselves - only one girl did that). Maybe one person attended a place like ATP. The rest of us were just plain, ordinary people. I don't think it matters nor whether it ever did.
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@jordane93 said, one advantage is that a qualified program will allow you to get an ATP (needed for a -121 job which includes cargo like UPS, FEDEX) is 1250 vs 1500. Another possible advantage is such programs have classes that can give you a leg up on the training. For me, I struggled with the concept of FMS and other flight automation because I never flew anything that had even a working autopilot. Some of these people had classes in FMS, turbines, and even CRJ systems. So, I was clueless when the cirriculum brought up terms like "green needles", discontinuities, flight control panel, etc. But most of us made it in the end so it was all good. For me, thank goodness for those people because they were the ones I went to for help.
If you enjoy astrophysics, just stay there. One of the great assets of the part 121 community is the diversity of backgrounds and education. People studied what they wanted and all ended up in the same place.
If your thought is that you can bypass the regionals for UPS or FEDEX, even in today's environment, I doubt you can do that. If you have a degree, the hours, and experience and not a screw-up, you should be able to get into a regional.