In 25 years of traveling, I know of one case of bed bugs that happened to a team member. The hotel (one of the Sheraton brands at the time) was amazing. When he called, they immediately said "we will take care of this." They sent a driver to pick him with a liner on the seat, took him to the nearby Westin, and escorted him to his new room. They gave him a robe and special soap to bathe with, took his clothes away and washed them. Meanwhile they washed all his clothes at the old hotel, sanitized his suite case and brought it all over to the Westin. After that was all clean, they helped him get his rental car replaced. They followed up every day for a week to make sure it was handled AND gave him like 100,000 points.
To me, that is still a jaw dropping response. Sadly, I think anything short of a 5 star hotel would not do the same today, they would be rather louse-y.