I think it's the other way around. We knew TNT's limits were more or less reached and math showed theoretical potential for the Manhattan project, so it was pursued..
But that's because there has always been a better, cheaper, more economical, easier solution to the things that needed energy. Steam / Coal / gas / etc., was always simply easier and cheaper than trying to build electric cars, electric Wright Flyers, electric ships..
200+ years later and billions of dollars spent we're not demonstrably closer. 18 minutes of flying time at 80 knots with a 370 lb (or whatever) useful load is honestly pathetic. Or.. 1 hr with a 10 minute reserve is close to suicidal.. that 10 minutes is hardly enough for one turn in the pattern after a go around. Good luck flying to your alternate after you don't break out at minimums