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I'm never going all that far, so 105-110 kts doesn't bother me.
A Sundowner that's properly rigged and with a CG aft of center (ballast weights are available) should do a bit better than that. I have a 1969 B23 Custom III, basically a SD with only one door, and she'll cruise at a little over 120 knots TAS.
Would you hesitate on this plane if you were out of a 2200 ft paved strip at sea level?
Yeah, I'd be a bit hesitant. Technically it'd work for density altitudes <4000'. The POH for my B23 says at 90F at sea level with no wind, I need 1566' to clear a 50' obstacle. But for
me, that's not enough margin, and like ChopAndDrop I really want 3000' if possible. I've flown off a 2600' runway and had no problems and room to spare, but 2200' is cutting things a bit closer than I'd like. When everything is working it'll be fine, but if you have to abort a takeoff you may have trouble getting it stopped.
That's a personal decision, though. The plane is technically capable of it, and a little headwind makes it less risky, as would a clear field after the runway (no 50' obstacle) and you say you have clear approaches.
These are excellent planes - very well built, few recurring ADs and none onerous, and they fly nicely. The interior is roomy and comfortable. No reason you couldn't use one for Commercial and CFI. Try to get a ride in one if you haven't already.